| 產(chǎn)品編號(hào) | bs-23550R-BF350 |
| 英文名稱(chēng) | Rabbit Anti-NCR1/BF350 Conjugated antibody |
| 中文名稱(chēng) | BF350標(biāo)記的細(xì)胞毒性受體NK-p46抗體 |
| 別 名 | Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335; CD 335; LY94; NCTR1_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NCR1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Subunit: Interacts with CD247 and FCER1G. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Selectively expressed by both resting and activated NK cells. Similarity: Belongs to the natural cytotoxicity receptor (NCR) family. Contains 2 Ig-like (immunoglobulin-like) domains. Database links: Entrez Gene: 9437 Human Entrez Gene: 17086 Mouse Omim: 604530 Human SwissProt: O76036 Human SwissProt: Q8C567 Mouse Unigene: 97084 Human Unigene: 240231 Mouse Unigene: 30049 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. NKp46是很重要的的自然細(xì)胞毒受體，在自然殺傷作用中起關(guān)鍵作用。細(xì)胞毒性受體家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表達(dá)于所有靜止和活化的NK細(xì)胞，而NKp44則選擇性的表達(dá)于活化的NK細(xì)胞。靶細(xì)胞上的配體分子與NCRs的結(jié)合（交聯(lián)）引發(fā)NK細(xì)胞的活化導(dǎo)致靶細(xì)胞的裂解和大量細(xì)胞因子的產(chǎn)生?，F(xiàn)已確認(rèn)NKp46和NKp44可以識(shí)別病毒上的配體分子紅血球凝聚素，而NKp46則能識(shí)別腫瘤細(xì)胞上的乙酰硫酸多聚糖。 |
