亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
精品一区二区三区无码av孕妇,在线视频精品免费
Rabbit Anti-SOCS7/FITC Conjugated antibody (bs-20151R-FITC)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-20151R-FITC
英文名稱 Rabbit Anti-SOCS7/FITC Conjugated antibody
中文名稱 FITC標(biāo)記的信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子7抗體
別    名 NAP 4; NAP 4 Fragment; NAP4; Nck Ash and phospholipase C binding protein; Nck Ash and phospholipase C gamma binding protein; Nck associated protein 4; NCKAP4; SH2 domain containing SOCS box protein; SOCS 7; SOCS4; SOCS6; Suppressor of cytokine signaling 7;SOCS7_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  淋巴細(xì)胞  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SOCS7
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes. SOCS6 and SOCS7 are expressed ubiquitously in murine tissues and SOCS6 knockout mice are growth retarded.

Function:
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Subunit:
Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6.

Subcellular Location:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.

Tissue Specificity:
Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.

Similarity:
Contains 1 SH2 domain.
Contains 1 SOCS box domain.

Database links:

Entrez Gene: 30837 Human

Omim: 608788 Human

SwissProt: O14512 Human

SwissProt: Q8WXH5 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
WWW国产成人免费观看视频 | 99热成人精品国产免男男 | 男女无套内射白将在线线国语 | 扒开老师大腿猛进AAA片软件 | 波多野结衣高清无碼中文字幕 | 亚洲欧洲校园自拍都市 | 在线综合亚洲欧美网站无弹窗 | 国产午夜无码91精品免费看 | 国产精品久久久天天影视香蕉 | 国产720刺激在线视频 | 99热国产在线精品99 | 欧美性猛交aaaaa免费看 | 久久久精品日韩免费观看 | 任我鲁精品视频精品 | 又粗又大又黄的少妇毛片 | 久久久久久精品成人免费 | 人妖欧美一区二区三区四区 | 五月丁香综合缴情六月 | 免费午夜扒丝袜www在线看 | 成人无码精品1区2区3区免费看 | 美梦视频大全免费观看 | 鲁人人人鲁人人鲁精品 | 国产精品乱码一区二区三区 | 国产精品综合日韩精品第一页 | 久久精品国产免费 | 亚洲中文字幕精品久久app | 91精品国产乱码久久无码 | 91精品国产综合久久精品色欲 | 久久久这里只有精品加勒比 | 亚洲综合久久1区2区3区 | 久久精品视频免费 | 黃色AV片三級三級三級免费看 | 粉嫩的女同事24p | 少妇被躁爽到高潮无码人狍大战 | 国产精品一国产AV麻豆 | 巨胸爆乳美女露双奶头挤奶 | 国产a一级毛片爽爽影院无码 | 亚洲精品无码久久久久久久久 | 被三个男人绑着躁我好爽视频 | 亚洲一区精品在线 | 国产综合色香蕉精品五夜婷 |