| 產(chǎn)品編號(hào) | bs-5394R-Gold |
| 英文名稱 | Rabbit Anti-phospho-IL-1R1(Tyr496)/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的磷酸化白介素1受體1抗體 |
| 別 名 | IL1 Receptor I (phospho Y496); Antigen CD121a; CD121 antigen-like family member A; CD121A; CD121a antigen; D2S1473; IL 1; IL 1R 1; IL 1R alpha; IL 1RT1; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; IL1 inhibitor; IL1R; IL1R1; IL1R1_HUMAN; IL1RA; IL1RN; IL1RT1; Interleukin 1 receptor alpha type 1; Interleukin 1 receptor antagonist protein (IRAP); Interleukin 1 receptor type I; Interleukin receptor 1; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type I; P80. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 心血管 免疫學(xué) 干細(xì)胞 淋巴細(xì)胞 t-淋巴細(xì)胞 細(xì)胞因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, Horse, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human IL-1R1 around the phosphorylation site of Tyr496 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II(IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Subunit: The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Subcellular Location: Membrane; Single-pass type I membrane protein. Cell membrane (Probable). Secreted. Post-translational modifications: A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Similarity: Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain. Database links: Entrez Gene: 3554 Human Entrez Gene: 16177 Mouse Omim: 147810 Human SwissProt: P14778 Human SwissProt: P13504 Mouse Unigene: 516249 Human Unigene: 701982 Human Unigene: 896 Mouse Unigene: 9758 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IL-1RⅠ屬于新的信號(hào)受體家族Toll信號(hào)轉(zhuǎn)導(dǎo)通路蛋白，IL-1RⅠ在免疫和炎癥反應(yīng)的研究中占重要地位，是在很多感染 、炎癥性致病機(jī)制中起決定性作用的細(xì)胞因子，幾乎可作用于全身各種細(xì)胞，IL-1 與IL-1R1的結(jié)合可導(dǎo)致大量與免疫反應(yīng)和炎癥相關(guān)基因的表達(dá) ，包括細(xì)胞因子、細(xì)胞因子受體、急性期反應(yīng)物、生長(zhǎng)因子、胞外基質(zhì)、粘附分子等。IL-1R1/NF-κB信號(hào)通路是機(jī)體免疫反應(yīng)中十分重要的組成部分。白介素1受體I型 Interleukin 1 receptor I(IL-1RI) |
