| 產(chǎn)品編號 | bs-1143R-BF488 |
| 英文名稱 | Rabbit Anti-STAT6/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6抗體 |
| 別 名 | signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 發(fā)育生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 94kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human STAT6 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Function: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. Subunit: Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif. Subcellular Location: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. Post-translational modifications: Tyrosine phosphorylated following stimulation by IL-4 and IL-3. Similarity: Belongs to the transcription factor STAT family. Contains 1 SH2 domain. Database links: Entrez Gene: 6778 Human Entrez Gene: 20852 Mouse Omim: 601512 Human SwissProt: P42226 Human SwissProt: P52633 Mouse Unigene: 524518 Human Unigene: 121721 Mouse Unigene: 6880 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 信息轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子-6(signal transducer and activator of transcription-6，STAT6)是信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子(STAT)家族的一員，是一種94kD的蛋白質(zhì)。它通過JAK-STAT信號轉(zhuǎn)導(dǎo)途徑介導(dǎo)細(xì)胞因子IL-3、IL-4及IL-13誘導(dǎo)的基因表達，特別是在促進IL-4誘導(dǎo)的MHCⅡ類抗原及免疫球蛋白受體等的表達及Th2細(xì)胞和淋巴細(xì)胞的發(fā)育上發(fā)揮了重要的作用。 |
