亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
少妇性活BBBBBBBBB小说,香港日本三级在线播放,成 人 免费 黄 色 网站无毒下载 久久人人爽人人爽人人片AV不
Rabbit Anti-Phospho-PIM1(Tyr309)/Gold Conjugated antibody (bs-3353R-Gold)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3353R-Gold
英文名稱 Rabbit Anti-Phospho-PIM1(Tyr309)/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的磷酸化前病毒整合位點(diǎn)蛋白1抗體
別    名 PIM1 (phospho Y309); PIM1 (phospho Tyr309); Oncogene PIM 1; Oncogene PIM1; PIM 1; Pim 1 kinase; Pim 1 oncogene; PIM; Pim2; PIM3; Proto oncogene serine/threonine protein kinase Pim 1; Proviral integration site 1; Proviral integration site 2.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul(10nm  15nm  35nm
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human PIM1 around the phosphorylation site of Tyr309
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011].

Function:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerced by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.

Subunit:
Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins. Binds to RP9. Isoform 1, but not isoform 2, binds BMX. Isoform 2 interacts with CDKN1B and FOXO3. Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM1, ubiquitination and proteasomal degradation. Interacts with HSP90, this interaction stabilizes PIM1 protein levels. Interacts (ubiquitinated form) with HSP70 and promotes its proteosomal degradation. Interacts with CDKN1A. Interacts with CDC25C. Interacts (via N-terminal 96 residues) with CDC25A. Interacts with MAP3K5. Interacts with MYC.

Subcellular Location:
Isoform 2: Cytoplasm. Nucleus. Isoform 1: Cell membrane.

Tissue Specificity:
Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.

Post-translational modifications:
Autophosphorylated on both serine/threonine and tyrosine residues. Phosphorylated. Interaction with PPP2CA promotes dephosphorylation.
Ubiquitinated, leading to proteasomal degradation.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5292 Human

Entrez Gene: 18712 Mouse

Entrez Gene: 24649 Rat

Omim: 164960 Human

SwissProt: P11309 Human

SwissProt: P06803 Mouse

SwissProt: P26794 Rat

Unigene: 81170 Human

Unigene: 405293 Mouse

Unigene: 485038 Mouse

Unigene: 34888 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PIM1蛋白是絲氨酸/蘇氨酸蛋白激酶2家族成員,他參與細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)、細(xì)胞凋亡、轉(zhuǎn)錄調(diào)節(jié),在很多腫瘤中表達(dá),尤其是前列腺癌,表達(dá)水平較高。
版權(quán)所有 2004-2026 a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
伊人思思久99久女女精品视频 | 国产精品久久久久久久人热 | 欧美一区二区三区不卡免费 | 三级日本高清完整版热播 | 精品自拍视频五区六区在线观看 | 中文区中文字幕免费看 | 久久精品极品盛宴观看 | 国产福利在线免费 | 欧美自拍经典综合一区 | 久久精品国产免费观看频道 | 久久99久久99精品免视看国产四区 | 毛片成人永久免费视频 | 亚洲日韩中文字幕A∨ | 亚洲AV无码久久无遮挡 | 欧美日韩精品视频一区二区三区在线观看 | 无码中文字幕拍偷乱偷精品 | 无码中文字幕拍偷乱偷精品 | 久久久久久精品毛片A级按摩 | WWW国产内插视频 | 欧美一级高清AAA片免费观看 | 免费一级毛片不卡在线播放 | 美女视频黄a视频全免费网站色窝 | 久久精品天天爽夜夜爽 | 欧美中文字幕一区二区三区 | 天堂www中文在线天堂网 | 日韩精品午夜视频一区二区三区 | 免费永久观看美女视频网站网址 | 成 人 黄 色 免费 网站无毒 | 伊人久久大香线蕉成人综合网 | 亚洲欧美日韩中文加勒比 | 国产成人AV一区二区三区无码 | 色综合99久久久无码国产精品 | 全免费A级毛片免费看无码播放 | 又大又紧又粗c死你视频 | 日本一区二区无卡高清视频 | 国产成人无码AV麻豆 | 久久九九久精品国产综合 | 成全动漫视频在线观看完整版 | 中文字幕一区二区三区在线观看 | 欧美精品在欧美一区二区少妇 | 午夜熟女插插XX免费视频 |