亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
未满小14洗澡无码视频网站 ,中文字幕日韩人妻在线乱码,综合欧美亚洲首页在线播放
Rabbit Anti-PPP1R10/PE-Cy5 Conjugated antibody (bs-11666R-PE-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11666R-PE-Cy5
英文名稱(chēng) Rabbit Anti-PPP1R10/PE-Cy5 Conjugated antibody
中文名稱(chēng) PE-Cy5標(biāo)記的絲氨酸/蘇氨酸蛋白磷酸酶1調(diào)節(jié)亞基10抗體
別    名 PNUTS; CAT 53; CAT53; FB 19; FB19; FB19 protein; MHC class I region proline rich protein CAT53; p99; Phosphatase 1 nuclear targeting subunit; Phosphatase nuclear targeting subunit; PNUTS; PP1 binding protein of 114 kDa; PP1R10; Protein phosphatase 1 regulatory (inhibitor) subunit 10; Protein phosphatase 1 regulatory subunit 10; Serine/threonine protein phosphatase 1 regulatory subunit 10; PP1RA_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  Alzheimer's  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 99kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PPP1R10
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Eukaryotic protein phosphorylation and dephosphorylation on serine and threonine residues regulates numerous cell functions, including division, homeostasis and apoptosis. A group of proteins that play a major role in this process are the serine/threonine protein phosphatases. Protein phosphatase (PP) holoenzyme is a trimeric complex that contains a regulatory subunit, a variable subunit and a catalytic subunit. Families of PP catalytic subunits include PP1, PP2A, PP2B, PP2C, PPX and PP5. Regulatory subunits include nuclear inhibitor of PP1 (NIPP1), PP1 nuclear targeting subunit (PNUTS), PP2A-A, PP2A-B, PP2A-B56, PP2A-C, PP2B-B and PR48. PNUTS, also designated CAT53 or FB19, is encoded by the gene PPP1R10. PNUTS acts as an inhibitor for the phosphatase activity of PP1 Alpha and PP1 Gamma. It is a nuclear protein primarily detected in nucleoplasmic bodies and within nucleoli. PNUTS expression levels are highest in brain, heart, lung, placenta, liver, kidney, pancreas and skeletal muscle.

Function:
PPP1R10 (serine/threonine protein phosphatase 1 regulatory subunit 10), also known as PNUTS, is a targeting subunit of protein phosphatase 1 (PP1). Furthermore, PPP1R10 acts as an inhibitor of PPP1CA and PPP1CC phosphatase activities. Its inhibitory activity on PPP1CA is only observed when PPP1R10 is phosphorylated by Protein Kinase A (PKA). PPP1R10 contains a zinc finger motif and is predominantly localised within the nucleus. Recently, PPP1R10 has been shown to target PP1 to GABA(C) receptors, shuttling from the nucleus to the cell membrane in cells co-expressing this receptor. This highlights a role for this protein in the regulation of synaptic signal transduction. PPP1R10 has also been shown to regulate the activity of p53 in response to hypoxia.

Subunit:
Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4

Subcellular Location:
Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase

Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Post-translational modifications:
Phosphorylated on Ser-398 and Thr-400 by PKA within the region necessary for interaction with PPP1CA

Similarity:
Contains 1 C3H1-type zinc finger.
Contains 1 TFIIS N-terminal domain.

Database links:

Entrez Gene: 5514 Human

Omim: 603771 Human

SwissProt: Q96QC0 Human

Unigene: 106019 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
色偷偷偷久久伊人大杳蕉 | 欧美日韩不卡合集视频 | 美女脱了奶罩看到大乳 | 欧美制服丝袜国产日韩一区 | 国产日韩精品一区二区三区在线 | 漂亮人妻被中出中文字幕色 | 欧亚成年男女深夜百度网盘 | 色久综合网精品一区二区 | 日本少妇AA一级特黄大片 | 国产真人无码作爱视频 | 中文字幕在线成人免费看 | 欧美四虏免费一级成人片 | 又大又粗进出白浆直流视频在线 | 久久久久久亚洲av无码专区 | 精品熟女碰碰人人A久久 | 久久人人做人人爽久久99国产乱子伦精品免 | 最近高清中文字幕无吗免费看 | 午夜福利免费一区二区小说 | 亚洲第一免费播放区 | 少妇无码太爽了视频在线播放 | 亚洲欧美激情精品一区二区 | 久久国产精品偷任你爽任你A | 中文精品字幕国产91久久久久久黄无码 | 久久狠狠爱亚洲综合影院 | 国产午夜一级鲁丝片 | 国产第一页浮力影院草草 | 国产无遮挡色视频免费观看性色 | 荡公乱妇蒂芙尼中文字幕 | 人妻妺妺窝人体色WWW聚色窝 | 好黄好猛好爽好痛的视频 | 亚洲999精品视频免费观看 | 中文字幕人妻一区二区在线视频 | 91麻豆精品激情在线观看最新 | 欧美.日韩.日本国产视频 | 国产拍揄自揄免费观看 | 一级做a爱过程免费视频超级 | 国产精品久久一区二区三蜜桃 | 亚洲人妻少妇av资源网站 | 麻豆一二三区AV传媒 | 高清无码视频在线观看 | 最近中文字幕在线看免费完整版 |