亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
69久久夜色精品国产69小说,中文字幕久久久久久一区二区三区 ,日韩一区二区三区精品
Rabbit Anti-Axin1/PE-Cy7 Conjugated antibody (bs-2439R-PE-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2439R-PE-Cy7
英文名稱 Rabbit Anti-Axin1/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的軸蛋白1抗體
別    名 AI316800; AXIN; Axin 1; Axin-1; axin1; AXIN1_HUMAN; Axis inhibition protein 1; Axis Inhibitor 1; Fu; fused; Fused, mouse, homolog of; hAxin; Kb; Ki; kinky; knobbly; MGC132911; MGC52315; PPP1R49; Protein Fused; Protein phosphatase 1 regulatory subunit 49.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 99kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Axin1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

Function:
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

Subcellular Location:
Cytoplasm. Nucleus. Cell membrane. MACF1 is required for its translocation to cell membrane. On UV irradiation, translocates to the nucleus and colocalizes with DAAX.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Sumoylation at Lys-857 and Lys-860 prevents ubiquitination and degradation. Sumoylation is required for AXIN1-mediated JNK activation. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important for nuclear accumulation during Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.

DISEASE:
Defects in AXIN1 are involved in hepatocellular carcinoma (HCC) [MIM:114550].
Defects in AXIN1 are a cause of caudal duplication anomaly (CADUA) [MIM:607864]. Caudal duplication anomaly is characterized by the occurrence of duplications of different organs in the caudal region. Note=Caudal duplication anomaly is associated with hypermethylation of the AXIN1 promoter.

Similarity:
Contains 1 DIX domain.
Contains 1 RGS domain.

Database links:

Entrez Gene: 8312 Human

Entrez Gene: 395786 Chicken

Entrez Gene: 504357 Cow

Entrez Gene: 100065116 Horse

Entrez Gene: 12005 Mouse

Entrez Gene: 79257 Rat

Omim: 603816 Human

SwissProt: O42400 Chicken

SwissProt: O15169 Human

SwissProt: O35625 Mouse

SwissProt: O70239 Rat

Unigene: 592082 Human

Unigene: 23684 Mouse

Unigene: 31781 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产无套内射又大又猛又粗又爽 | 亚瑟TV私人网站 | 欧美国产一区二区三区激情无套 | 久久久久久久国产免费看 | 在线观看免费av网站 | 欧美人妻AⅤ中文字幕 | 一级毛片在线播放免费观看 | 国产成人一区免费观看 | 久久97久久精品免费观看黑人 | 好吊妞视频这里有精品 | 亚洲欧美日韩综合在线观看 | 最近日本字幕MV高清在线观看 | 最近免费中文字幕MV免费高清版 | 欧美性受XXXX黑人XYX性爽 | 久久国产亚洲电影天堂 | 国产亚洲午夜精品a一区二区 | 精品少妇AV无码免费久久洗澡 | 精品成a人亚洲精品无码 | 国产又湿又黄又硬又刺激视频 | 亚洲AV综合色一区二区三区 | 国产在线观看无码免费视频 | 国产又黄又爽无遮挡动态图 | 国产色XX群视频射精 | 国产精品沙发午睡系列990531 | 亚洲无线一二三四区手机 | 大桥未久加勒比女热大陆在线 | 连续高潮抽搐爽死喷水流白浆无码 | 91精品国产高清一区二区三密臀 | 国产精品免费露脸视频 | 免费视频国产在线观看 | 中文精品一区二区三区四区 | 色婷婷AV一区二区三区在线观看 | 超碰97人人做人人爱亚洲尤物 | 在线看片免费人成视频电影sM | 狼人香蕉香蕉在线28 | 欧美在线成人免费观看网站 | 亚州一级一片无码内射 | 男女激情射精国产精品久久 | 狠狠色丁香久久婷婷综合_中 | 人人妻人人添人人爽欧美一区91 | 国产AV一区二区三区最新精品 |