亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
校园久久综合激情四射伊人丁香,日韩AV在线高清免费毛片
Rabbit Anti-HDAC3/BF350 Conjugated antibody (bs-1819R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1819R-BF350
英文名稱 Rabbit Anti-HDAC3/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的組蛋白去乙酰化酶3抗體
別    名 RPD3 2; RPD3-2; HD 3; HD3; HDAC 3; Histone deacetylase 3 (HD3) (RPD3-2); histone deacetylase 3; RPD 3; RPD3; SMAP 45; SMAP-45; SMAP45; HDAC3_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  發(fā)育生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HDAC3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

Subunit:
Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Sumoylated in vitro.

Similarity:
Belongs to the histone deacetylase family. HD type 1 subfamily.

Database links:

Entrez Gene: 8841 Human

Entrez Gene: 15183 Mouse

Entrez Gene: 84578 Rat

Omim: 605166 Human

SwissProt: O15379 Human

SwissProt: O88895 Mouse

SwissProt: Q6P6W3 Rat

Unigene: 519632 Human

Unigene: 20521 Mouse

Unigene: 17284 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

組蛋白去乙酰化酶(HDACs)是一組在細(xì)胞染色質(zhì)水平、通過誘導(dǎo)組蛋白去乙酰化來調(diào)控包括染色質(zhì)重組、轉(zhuǎn)錄活化或抑制、細(xì)胞周期、細(xì)胞分化及細(xì)胞凋亡等一系列生物學(xué)效應(yīng)的酶,特別是與細(xì)胞活化后的基因轉(zhuǎn)錄表達(dá)調(diào)控有關(guān)。
版權(quán)所有 2004-2026 a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产在线精品福利大全 | 五月丁香综合缴情六月 | 久久黄色免费网站 | 国产v综合v亚洲欧美大片 | 色欲精品久久人妻av中文字幕 | 日本精品久久久久中文字幕 | 欧美最猛性xxxxx亚洲精品 | 91精品国产乱码久久久久久 | 成全视频免费高清观看在线 | 国产中文字幕久久精品网址 | 一区二区视频在线观看高清视频在线 | 日韩免费视频在线观看免费 | 55大东北熟女啪啪嗷嗷叫 | 国产成人AV在线播放影院 | 国产午夜三级一区二区三 | YW尤物爆乳网站点击进入 | 一本一道精品欧美中文字幕 | 国模冰莲2013肥美人体自慰w | 成全视频免费高清观看在线 | 麻豆一区二区免费播放网站 | 亚洲AⅤ日韩久久久久久 | 少妇性荡欲午夜性开放视频剧场 | 亚洲中文字幕在线乱妇 | 熟妇高潮一区二区在线播放 | 久久91精品国产91久久户 | 成熟少妇大片免费看 | 91精品在线免费视频 | 久久久久久成人毛片免费看 | 国产精品免费视频一区二区三区 | 精品1区2区3区产品乱码 | 女人被狂躁到爽动态gif图 | 日产精品美女久久久网站大全 | 又大又紧又粗C死你视频 | 爽到高潮无码视频在线观看 | 在线观看日本污污ww网站 | 国产亚洲精品女人久久久久久 | 给我免费播放片在线中国 | 国产无套内射又大又猛又粗又爽 | 久久婷婷五月综合丁香人人爽 | 国产又湿又黄又硬又刺激视频 | 亚洲1区2区3区精华液 |