亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
夜鲁夜鲁很鲁在线视频视频,日韩精品视频美在线精品视频 ,2019年国产高清情侣视频
Rabbit Anti-HDAC3/RBITC Conjugated antibody (bs-1819R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1819R-RBITC
英文名稱 Rabbit Anti-HDAC3/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的組蛋白去乙?;?抗體
別    名 RPD3 2; RPD3-2; HD 3; HD3; HDAC 3; Histone deacetylase 3 (HD3) (RPD3-2); histone deacetylase 3; RPD 3; RPD3; SMAP 45; SMAP-45; SMAP45; HDAC3_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  發(fā)育生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HDAC3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

Subunit:
Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Sumoylated in vitro.

Similarity:
Belongs to the histone deacetylase family. HD type 1 subfamily.

Database links:

Entrez Gene: 8841 Human

Entrez Gene: 15183 Mouse

Entrez Gene: 84578 Rat

Omim: 605166 Human

SwissProt: O15379 Human

SwissProt: O88895 Mouse

SwissProt: Q6P6W3 Rat

Unigene: 519632 Human

Unigene: 20521 Mouse

Unigene: 17284 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

組蛋白去乙?;?HDACs)是一組在細(xì)胞染色質(zhì)水平、通過誘導(dǎo)組蛋白去乙酰化來調(diào)控包括染色質(zhì)重組、轉(zhuǎn)錄活化或抑制、細(xì)胞周期、細(xì)胞分化及細(xì)胞凋亡等一系列生物學(xué)效應(yīng)的酶,特別是與細(xì)胞活化后的基因轉(zhuǎn)錄表達(dá)調(diào)控有關(guān)。
版權(quán)所有 2004-2026 a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
麻豆国产精品无码AV在线 | 欧美日韩在线精品一区二区三区激情综合 | 久久免费观看视频 | 欧美第一区重口sm虐性奴视频 | 97久久久人妻一区精品 | 人体内射精一区二区三区 | 国产又大又粗又长硬又紧又爽 | 女老板又大又紧水又多 | 熟女少妇一区二区中文字幕 | 在线观看中文最近最新观看 | 亚洲精品欧美精品日韩精品 | 一本视频精品中文字幕 | 啊灬啊灬啊灬快灬性 | 国产精品无码午夜福利免费看 | 国产后进白嫩翘臀在线动漫 | 亚洲AV无一区二区三区 | 特黄三级又爽又粗又大洗澡 | 欧美一区二区三区免费视频 | 国产99久久亚洲综合精品 | 国产内射老熟女AAAA | 天天躁日日躁狠狠躁日日躁黑人 | 香港三级精品三级在线专区 | 成人午夜黄网站在线观看 | 久久久久久精品成人免费 | 国产V片在线播放免费观看大全 | 女生扒开私处让男生插的 | 在线观看视频一区 | 欧美黑人疯狂性受XXXXX喷水 | 公与淑婷厨房猛烈进出视频韩国 | 久久午夜一区二区 | 国产禁忌A级毛片中字内射 亚洲AV福利天堂一区二区三 | 被两个两个黑人吃奶4P | 中文字幕人妻偷人伦在线视频 | 精品免费囯产一区二区三区四区 | 午夜一区欧美二区高清三区 | 初高中生洗澡福利网站 | 欧美日韩久久久精品A片 | 亚洲精品白浆高清久久久久久 | 又粗又大又黄的少妇毛片 | 日本有码在线中文字幕 | 欧美牲交A欧美牲交VDO |