| 產(chǎn)品編號(hào) | IHC0488R |
| 英文名稱 | Rat P4HB Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠蛋白質(zhì)二硫鍵異構(gòu)酶即用型免疫組化試劑盒 |
| 別 名 | CLCRP1; DSI; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; PDI; PDIA1; PDIR; PHDB; PO4DB; PO4HB; PROHB; Thbp |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). PDI may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. SWISS: P07237 Gene ID: 5034 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded rat brain tissue slide using IHC0488R (Rat P4HB IHC Kit).
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