| 產(chǎn)品編號(hào) | bsm-52043M |
| 英文名稱 | CCNA2 Mouse mAb |
| 中文名稱 | 周期素A2單克隆體 |
| 別 名 | CCNA2_HUMAN; Cyclin-A2; Cyclin-A; CCN1; CCN1; CCNA; cyclin A2; |
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Specific References (1) | bsm-52043M has been referenced in 1 publications.
[IF=2.65] Ruoyang Lin. et al. Inhibitory Effects of Rabdosia rubescens in Esophageal Squamous Cell Carcinoma: Network Pharmacology and Experimental Validation. EVID-BASED COMPL ALT. 2022 Nov 10;2022:2696347 WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 細(xì)胞周期蛋白 |
| 抗體來(lái)源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號(hào) | 2E9 |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:50-200,IF=1:50-200,ICC/IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 49 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human CCNA2 protein (1-150aa) |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016] Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. Subunit: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER. Subcellular Location: Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER. Post-translational modifications: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. Similarity: Belongs to the cyclin family. Cyclin AB subfamily. SWISS: P20248 Gene ID: 890 Database links: Entrez Gene: 890 Human Entrez Gene: 12428 Mouse Omim: 123835 Human SwissProt: P20248 Human SwissProt: P51943 Mouse Unigene: 58974 Human Unigene: 4189 Mouse Unigene: 13094 Rat |
