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IL-1 Beta Rabbit pAb (bs-20449R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號 bs-20449R
英文名稱 IL-1 Beta Rabbit pAb
中文名稱 白介素1β/IL-1β抗體
別    名 IL1B_HUMAN; Interleukin-1 beta; interleukin 1 beta; IL1F2; IL-1 beta; Catabolin; IL-1; IL1F2; IL1beta; IL1-BETA; IL-1beta; IL-1 beta; IL-1β; IL1β; IL-1B; IL1B;  
Specific References  (12)     |     bs-20449R has been referenced in 12 publications.
[IF=7.233] Chen X et al. A photothermal-triggered nitric oxide nanogenerator combined with siRNA for precise therapy of osteoarthritis by suppressing macrophage inflammation.Nanoscale.?2019 Apr 4;11(14):6693-6709.  IHC-P&IF ;  Mouse.  
[IF=7.097] Chuping Zheng. et al. The cellular immunotherapy of integrated photothermal anti-oxidation Pd-Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis. Acta Pharm Sin B. 2021 Mar;:  IF,IHC ;  Mouse.  
[IF=6.533] Hui He. et al. Patchouli alcohol ameliorates depression-like behaviors through inhibiting NLRP3-mediated neuroinflammation in male stress-exposed mice. J AFFECT DISORDERS. 2023 Jan;:  WB ;  Mouse.  
[IF=5.047] Chen X et al. Targeted Hexagonal Pd Nanosheets Combination Therapy Rheumatoid Arthritis via Photothermal Control Release MTX. Journal of Materials Chemistry B. 2019, 7, 112.  IHC-P ;  Mouse.  
[IF=4.486] Mingying Han. et al. Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway. 2021 May 24  WB ;  Mouse.  
[IF=4.012] Xiaoliang Hua. et al. CXCR3 antagonist AMG487 ameliorates experimental autoimmune prostatitis by diminishing Th1 cell differentiation and inhibiting macrophage M1 phenotypic activation. PROSTATE. 2022 Jun 14  IHC ;  Mouse.  
[IF=3.647] Jian Zhou. et al. A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH. Life Sci. 2021 Jul;276:119403  WB ;  Mouse.  
[IF=3.553] Wu Z et al. Pyroptosis engagement and bladder urothelial cells derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after UPEC infection. Am J Physiol Cell Physiol. 2019 Jun 26.  WB ;  Mouse.  
[IF=3.37] Chujie Qu. et al. Nuclear receptor TLX may be through regulating the SIRT1/NF-κB pathway to ameliorate cognitive impairment in chronic cerebral hypoperfusion. Brain Res Bull. 2021 Jan;166:142  WB ;  Rat.  
[IF=3.264] Zhou Junjie. et al. Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats. BMC NEUROSCI. 2023 Dec;24(1):1-14  WB ;  Rat.  
[IF=2.772] Wu L et al. Notch Signaling Regulates Microglial Activation and Inflammatory Reactions in a Rat Model of Temporal Lobe Epilepsy.Neurochemical Research,2018 43(6), 1269–1282.  WB ;  Rat.  
[IF=1.512] Yizhen Lyu. et al. Alterations of IL-1beta and TNF-alpha expression in RAW264.7 cell damage induced by two samples of PM2.5 with different compositions:. SCI PROGRESS-UK. 2022;105(3):  WB ;  Mouse.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  糖蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Mouse (predicted: Human,Rat,Bee)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 17/32 kDa
檢測分子量
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-1 Beta: 181-269/269 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].

Function:
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Subunit:
Monomer.

Subcellular Location:
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Similarity:
Belongs to the IL-1 family.

SWISS:
P01584

Gene ID:
3553

Database links:

Entrez Gene: 3553 Human

Entrez Gene: 16176 Mouse

Entrez Gene: 24494 Rat

Omim: 147720 Human

SwissProt: P01584 Human

SwissProt: P10749 Mouse

SwissProt: Q63264 Rat

Unigene: 126256 Human

Unigene: 222830 Mouse

Unigene: 9869 Rat



產(chǎn)品圖片
Sample: Hemocyte (Mouse) Lysate at 40 ug Primary: Anti-IL-1 Beta (bs-20449R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 17 kD Observed band size: 30 kD
Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti-IL-1 Beta (bs-20449R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 17kD Observed band size: 16kD
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