亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
艳妇乳肉豪妇荡乳AV无码福利,91精品久久久久久中文字幕
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
STIM1 Rabbit pAb (bs-8526R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產(chǎn)品編號 bs-8526R
英文名稱 STIM1 Rabbit pAb
中文名稱 基質(zhì)交感分子1抗體
別    名 GOK; SIM; STIM 1; STIM-1; Stim1 stromal interaction molecule 1; STIM1_HUMAN; STIM1L; Stromal interaction molecule 1.  
研究領(lǐng)域 腫瘤  細胞生物  信號轉(zhuǎn)導  通道蛋白  細胞表面分子  淋巴細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Rat (predicted: Human,Mouse,Rabbit,Pig,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 75 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human STIM1: 85-180/685 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.

Function:
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.

Subunit:
Forms homooligomers and heterooligomers with STIM2. Interacts with ORAI1. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and ORAI1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with TMEM66/SARAF, promoting a slow inactivation of STIM1-dependent SOCE activity, possibly by facilitating the deoligomerization of STIM1.

Subcellular Location:
Cell membrane. Endoplasmic reticulum membrane. Cytoplasm > cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing distal tip of microtubules.

Tissue Specificity:
Ubiquitously expressed in various human primary cells and tumor cell lines.

Post-translational modifications:
Glycosylation is required for cell surface expression.
Phosphorylated predominantly on Ser residues.

DISEASE:
Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.

Similarity:
Contains 1 EF-hand domain.
Contains 1 SAM (sterile alpha motif) domain.

SWISS:
Q13586

Gene ID:
6786

Database links:

Entrez Gene: 6786 Human

Entrez Gene: 20866 Mouse

Entrez Gene: 361618 Rat

Omim: 605921 Human

SwissProt: Q13586 Human

SwissProt: P70302 Mouse

SwissProt: P84903 Rat

Unigene: 501735 Human

Unigene: 645 Mouse

Unigene: 106771 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (STIM1) Polyclonal Antibody, Unconjugated (bs-8526R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
版權(quán)所有 2004-2026 a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产又色又爽又黄刺激蜜臀AV | 少妇野外一级内射婬片免费放 | 国产一级a毛一级a看免费视频 | 丝袜自慰一区二区三区四区 | 亚洲人AV永久一区二区三区久久 | 日本黄H兄妹H动漫一区二区三区 | 国产又粗又猛又爽又黄的视频 | 91精品在线免费视频 | 国产亚洲自拍一区 | 亚洲AV成人一区二区三区在线看 | 欧美人妻AⅤ中文字幕 | 懂色av无码aV天天aV天天爽 | 51视频精品全部免费视频 | 日韩欧美视频一区二区 | 日本不卡免费高清视频 | 国产精品天天影视久久综合网 | 99九九精品国产高清自在线 | 高清少妇熟女一区二区 | 蜜桃臀无码内射一区二区三区 | 国产AV影片久久久久久 | 向日葵视频APP秋葵榴莲网站 | 一本视频精品中文字幕 | 公办室系办系奷系奷系 | 性欧美video另类hd亚洲人 | 天天摸夜夜躁躁到高潮av | 欧美一级婬人妻欧美大片 | 无码不卡免费v片在线观看 国产未发育呦交视频 | 国产720刺激在线视频 | 国产一级特黄aa毛片 | 成人夜剧电影在线播放 | 91精品国产制服啪啪无码 | 国产精品日本不卡一区二区 | 色天天爱天天狠天天透 | 亚洲中文字幕在线一区播放 | 99久久久精品综合网 | 中文字幕乱码高清免费网 | 羞羞汗汗YY歪歪漫画AV漫画 | 黄色网页免费观看 | 蜜臀AV一区二区三区人妻在线 | 爱情岛网站亚洲禁18进入 | 中文字幕不卡一区二区三区 |