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CD19 Rabbit pAb (bs-4755R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號(hào) bs-4755R
英文名稱 CD19 Rabbit pAb
中文名稱 CD19抗體
別    名 CD19_HUMAN; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19; B-lymphocyte surface antigen B4; Leu 12; Leu12;  
Specific References  (3)     |     bs-4755R has been referenced in 3 publications.
[IF=3.484] Boon Ching Teeet al. Xenogeneic mesenchymal stem cell transplantation for mandibular defect regeneration. Xenotransplantation . 2020 Sep;27(5):e12625.  IHC ;  rat.  
[IF=1.396] Xiong Y et al. Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.(2018) Int J Clin Exp Pathol;11(10):4817-4826.  FC&IHC ;  Mouse.  
[IF=0.976] Sahiner et al. Impact of intravesical hyaluronic acid treatment on bladder inflammation in interstitial cystitis rat model. (2018) Int.Braz.J.Urol. 44:1014-1022  IHC ;  Rat.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  干細(xì)胞  細(xì)胞表面分子  淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Human,Mouse (predicted: Rat,Pig,GuineaPig)
產(chǎn)品應(yīng)用 Flow-Cyt=1μg /Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 59 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD19: 151-250/556 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 CD19 is a transmembrane glycoprotein that is delectively expressed on the cell surface of B-lymphocytes,where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways.Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

Function:
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

Subunit:
Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Post-translational modifications:
Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.

DISEASE:
Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
P15391

Gene ID:
930

Database links:

Entrez Gene: 930 Human

Entrez Gene: 12478 Mouse

Omim: 107265 Human

SwissProt: P15391 Human

SwissProt: P25918 Mouse

Unigene: 652262 Human

Unigene: 4360 Mouse



CD19是一種質(zhì)膜蛋白質(zhì),參與信號(hào)傳導(dǎo)作用。表達(dá)與前B細(xì)胞和成熟的B細(xì)胞膜表面,與B細(xì)胞的活化調(diào)節(jié)和發(fā)育調(diào)節(jié)相關(guān),在T細(xì)胞和正常粒細(xì)胞上無表達(dá)。此抗體可以特異性識(shí)別CD19,主要用于標(biāo)記正常B細(xì)胞及腫瘤性B細(xì)胞。
產(chǎn)品圖片
Blank control (blue line): HL60 cells (fixed with 70% methanol (Overnight at 4℃)). Primary Antibody (green line): Rabbit Anti-CD19 antibody (bs-4755R),Dilution: 0.2 μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE,Dilution: 1μg /test.
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