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ADAM11 Rabbit pAb (bs-5846R)  
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產(chǎn)品編號(hào) bs-5846R
英文名稱 ADAM11 Rabbit pAb
中文名稱 去整合素樣金屬蛋白酶11抗體
別    名 A disintegrin and metalloproteinase domain 11; ADA11_HUMAN; MDC; Metalloproteinase like, disintegrin like, and cysteine rich protein.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞骨架  細(xì)胞外基質(zhì)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat,Sheep,Cow)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 60 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADAM11: 351-450/769 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Jul 2008].

Function:
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

Subunit:
Can bind to LGI1 and LGI4.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed predominantly in brain. Slightly detected or not at all in other tissues.

Post-translational modifications:
The precursor is cleaved by a furin endopeptidase.

Similarity:
Contains 1 disintegrin domain.
Contains 1 EGF-like domain.
Contains 1 peptidase M12B domain.

SWISS:
O75078

Gene ID:
4185

Database links:

Entrez Gene: 4185 Human

Omim: 155120 Human

SwissProt: O75078 Human

Unigene: 6088 Human



細(xì)胞外基質(zhì)蛋白
產(chǎn)品圖片
Sample: A549 Cell (Human) Lysate at 40 ug Primary: Anti-ADAM11 (bs-5846R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60 kD Observed band size: 60 kD
Sample: brain (Mouse) Lysate at 40 ug Primary: Anti-ADAM11 (bs-5846R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60 kD Observed band size: 60 kD
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