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KLRB1 Rabbit pAb (bs-2807R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-2807R
英文名稱 KLRB1 Rabbit pAb
中文名稱 CD161抗體
別    名 KLRB1_HUMAN; Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; NKR; CD161; CLEC5B; NKR-P1; NKRP1A.  
Specific References  (1)     |     bs-2807R has been referenced in 1 publications.
[IF=3.491] Yukiko Nagahara. et al. Corneal Opacity Induced by Light in a Mouse Model of Gelatinous Drop-Like Corneal Dystrophy. Am J Pathol. 2020 Dec;190:2330  IHC ;  Mouse.  
研究領(lǐng)域 免疫學(xué)  干細(xì)胞  細(xì)胞類型標(biāo)志物  自然殺傷細(xì)胞  淋巴細(xì)胞  t-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
產(chǎn)品應(yīng)用 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 25 kDa
檢測分子量 40-48
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD161: 151-225/225 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]

Function:
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

Subunit:
Contains 1 C-type lectin domain.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.

Post-translational modifications:
N-glycosylated. Contains sialic acid residues.

Similarity:
Contains 1 C-type lectin domain.

SWISS:
Q12918

Gene ID:
3820

Database links:

Entrez Gene: 3820 Human

SwissProt: Q12918 Human



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