| 產(chǎn)品編號(hào) | bs-0089R |
| 英文名稱 | Secretin receptor Rabbit pAb |
| 中文名稱 | 分泌素受體抗體 |
| 別 名 | 6530402O03Rik, MGC102218, MGC93381, SCTR, SR; Secretin receptor; SCT-R; SCTR_HUMAN. |
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Specific References (4) | bs-0089R has been referenced in 4 publications.
[IF=14.679] Lixian Chen. et al. Inhibition of secretin/secretin receptor axis ameliorates non‐alcoholic fatty liver disease phenotypes. 2021 Apr 30 IHC ; Human, Mouse.
[IF=9.274] Peder Berg. et al. Impaired Renal HCO3- Excretion in Cystic Fibrosis. J Am Soc Nephrol. 2020 Aug;31(8):1711-1727 IHC ; Mouse.
[IF=9.071] Lamei Xue. et al. Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring. EMBO REP. 2022 Jul;23(7):e54132 WB ; Human.
[IF=4.254] Zhou T et al. Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2-/- mice by diminishing senescence of cholangiocytes.Lab Invest. 2018 Nov;98(11):1449-1464 IHC-P ; Mouse.
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| 研究領(lǐng)域 | 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素 細(xì)胞膜受體 內(nèi)分泌病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 46 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Secretin receptor: 188-280/440 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The receptor for secretin is a class 2 (or class B) G protein coupled receptor that signals through Gs to stimulate cAMP production. Along with its traditional role in the pancreas, studies in secretin-deficient mice have shown miscommunication between the CA3 Schaffer collateral and CA1 pyramidal neurons, causing a deficiency in synaptic transmission. This miscommunication of CA1 dendrites is found in Autism, Rett Syndrome, and most forms of mental retardation, suggesting secretin could be a potential target for treatment of these disorders. Function: This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 2 family. SWISS: P47872 Gene ID: 6344 Database links: Entrez Gene: 6344 Human Omim: 182098 Human SwissProt: P47872 Human Unigene: 42091 Human |
| 產(chǎn)品圖片 |
Tissue/cell: mouse thyroid tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-Secretin receptor Polyclonal Antibody, Unconjugated(bs-0089R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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