| 產(chǎn)品編號 | bs-1177R |
| 英文名稱 | LINGO1 Rabbit pAb |
| 中文名稱 | Nogo受體反應(yīng)蛋白抗體 |
| 別 名 | FLJ14594; LERN 1; Lingo-1; LERN1; Lingo1; Leucine rich repeat and Ig domain containing 1; Leucine rich repeat neuronal protein 1; Leucine rich repeat neuronal protein 6A; Leucine-rich repeat neuronal 6A; Lingo 1; LRR and Ig domain-containing Nogo Receptor interating protein; Lrrn 6a; Lrrn6a; Lrrn6a protein; MGC17422; Nogo Receptor interacting protein; UNQ201. |
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Specific References (1) | bs-1177R has been referenced in 1 publications.
[IF=3.171] Huang Y et al. Mechanism of delayed encephalopathy after acute carbon monoxide poisoning. Neural Regen Res
. 2020 Dec;15(12):2286-2295. IHC-P ; Rat.
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| 研究領(lǐng)域 | 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 通道蛋白 細(xì)胞膜受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Pig,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 70 kDa |
| 檢測分子量 | 75-85 |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LINGO1: 521-620/620 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
LINGO-1 (LRR and Ig domain-containing Nogo Receptor interating protein) is a nervous system-specific LRR-Ig-containing protein with an important role in CNS biology. LINGO-1 was discovered in a sequence database search for human SLIT homologs that were selectively expressed in the brain. LINGO-1 is a transmembrane protein that is a component of the Nogo-66 receptor complex. It binds NgR1 and p75 and is an additional functional componenet of the NgR1/p75 signaling complex. Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. Subunit: Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients. Post-translational modifications: N-glycosylated. Contains predominantly high-mannose glycans. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 11 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Contains 1 LRRNT domain SWISS: Q96FE5 Gene ID: 84894 Database links: Entrez Gene: 415344 Chicken Entrez Gene: 84894 Human Entrez Gene: 235402 Mouse SwissProt: Q50L44 Chicken SwissProt: Q6NUK3 Human SwissProt: Q96FE5 Human SwissProt: Q9D1T0 Mouse 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology） LINGO-1是一種體內(nèi)體外少突膠質(zhì)細(xì)胞(Oligodendrocyte)分化和髓鞘(myelination)的負(fù)調(diào)控因子，神經(jīng)元上的LINGO-1被證明參與調(diào)節(jié)中樞神經(jīng)再生的抑制信號，而少突膠質(zhì)細(xì)胞表達(dá)的LINGO-1分子參與負(fù)調(diào)節(jié)少突膠質(zhì)細(xì)胞的髓鞘化過程，是一種體內(nèi)體外少突膠質(zhì)細(xì)胞(Oligodendrocyte)分化和髓鞘(myelination)的負(fù)調(diào)控因子。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Lingo-1) Polyclonal Antibody, Unconjugated (bs-1177R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Lingo-1) Polyclonal Antibody, Unconjugated (bs-1177R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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