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CRF Rabbit pAb (bs-0246R)  
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產(chǎn)品編號 bs-0246R
英文名稱 CRF Rabbit pAb
中文名稱 促腎上腺皮質(zhì)激素釋放因子/促腎上皮質(zhì)激素釋放激素抗體
別    名 Corticoliberin; Corticoliberin precursor; Corticotropin releasing factor; Corticotropin releasing hormone; Corticotropin releasing hormone deficiency included; crf; crh; crh deficiency included; corticoliberin preproprotein; CRF_HUMAN; Corticotropin-relea  
Specific References  (4)     |     bs-0246R has been referenced in 4 publications.
[IF=15.071] Balan et al. The GABAA Receptor α2 Subunit Activates a Neuronal TLR4 Signal in the Ventral Tegmental Area that Regulates Alcohol and Nicotine Abuse. (2018) Brain.Sci. 8  WB ;  human.  
[IF=6.208] Steven L. Bernstein. et al. Neuroprotection and Neuroregeneration Strategies Using the rNAION Model: Theory, Histology, Problems, Results and Analytical Approaches. INT J MOL SCI. 2022 Jan;23(24):15604  IHC ;  Rat.  
[IF=5.96] Balan, Irina, et al. "Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity." Brain, Behavior, and Immunity(2017).  WB, IF(ICC) ;  Rat.  
[IF=3.096] Roland Csurgyók. et al. Expression of Wilms-tumor 1 antigen, vimentin and corticotropin releasing factor in human kidney with focal segmental glomerulosclerosis and effect of oxidative stress on these markers in HEK 293 cells. KIDNEY BLOOD PRESS R. 2022 Dec;:1  IF, TEM ;  Human.  
研究領域 神經(jīng)生物學  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,Rat (predicted: Human,Rabbit,Pig,Chicken,Dog,GuineaPig)
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 5/22 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human CRF protein: 25-196/196 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010].

Function:
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.

Subunit:
Interacts (via C-terminus) with CRFR1 (via N-terminalv extracellular domain).

Subcellular Location:
Secreted.

Similarity:
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

SWISS:
P06850

Gene ID:
1392

Database links:

Entrez Gene: 1392 Human

Entrez Gene: 12918 Mouse

Entrez Gene: 81648 Rat

Omim: 122560 Human

SwissProt: P06850 Human

SwissProt: Q8CIT0 Mouse

SwissProt: P01143 Rat

Unigene: 75294 Human

Unigene: 290689 Mouse

Unigene: 10349 Rat



CRF陽性神經(jīng)元的胞體廣泛分布于下丘腦的室旁核、背縫核和藍斑核,這些區(qū)域也是去甲腎上腺素(NE)神經(jīng)元與5-羥色胺(5-HT)神經(jīng)元密集的區(qū)域。
CRF既具有神經(jīng)遞質(zhì)的性質(zhì)又具有神經(jīng)激素的性質(zhì)。CRF是聯(lián)系神經(jīng)系統(tǒng)與內(nèi)分泌系統(tǒng)的橋梁,在情感障礙疾患如焦慮和抑郁的發(fā)病中發(fā)揮重要作用.
產(chǎn)品圖片
25 ug total protein per lane of various lysates (see on figure) probed with CRF polyclonal antibody, unconjugated (bs-0246R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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